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In an open-label phase II trial, curcumin treatment (8 g/day) in combination with the anticancer drug gemcitabine was associated with severe abdominal pain in 7 out of 17 patients with advanced pancreatic cancer, leading to the treatment being discontinued in five patients while curcumin dosage was reduced to 4 g/day in two patients (79)

Ferulic acid (from Angelica sinensis and Ligusticum chuanxiong) and astragaloside IV (from Astragalus) have similarly demonstrated reduction in cardiac fibrosis and improved post-MI ventricular function, linked to modulation of inflammatory cytokines and collagen synthesis (Lu et al., 2015

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Bearberry Extract: Bearberry (Uva Ursi, Arbutin) can have melanin-inhibiting properties and are considered safe alternatives to commonly used depigmenting agents to make the skin fairer

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239.) Available from: Vitamin B12, Fact Sheet for Health Professionals, National Institutes of Health, Office of Dietary Supplements Vitamin B12, Fact Sheet for Health Professionals, National Institutes of Health, Office of Dietary Supplements Homocysteine, Cleveland Clinic,